R.A. Kirken: search on Z-Library

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1

Regulation of T cell homeostasis by JAKs and STATs

Jeremy A. Ross, Zsuzsanna S. Nagy, Hanyin Cheng, Stanislaw M. Stepkowski, Robert A. Kirken

Journal:

Archivum Immunologiae et Therapiae Experimentalis

Year:

2007

Language:

english

File:

PDF, 2.01 MB

english, 2007

2

STAT3: An Important Regulator of Multiple Cytokine Functions

Stepkowski, Stanislaw M., Chen, Wenhao, Ross, Jeremy A., Nagy, Zsuzsanna S., Kirken, Robert A.

Journal:

Transplantation Journal

Year:

2008

Language:

english

File:

PDF, 545 KB

english, 2008

3

Integration of a Personalized Molecular Targeted Therapy into the Multimodal Treatment of Refractory Childhood Embryonal Tumor with Multilayered Rosettes (ETMR)

Hartman, Lisa L.R., Oaxaca, Derrick M., Carcamo, Benjamin, Wilson, Harry L., Ross, Jeremy A., Robles-Escajeda, Elisa, Kirken, Robert A.

Journal:

Case Reports in Oncology

Year:

2019

Language:

english

File:

PDF, 509 KB

english, 2019

4

Direct killing of interleukin-2-transfected tumor cells by human neutrophils

Federica Pericle, Robert A. Kirken, P. K. Epling-Burnette, D. Kay Blanchard, Julie Y. Djeu

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 885 KB

english, 1996

5

Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene

Rafael E. Curiel, Riitta Lahesmaa, Jeff Subleski, Marco Cippitelli, Robert A. Kirken, Howard A. Young, Paritosh Ghosh

Journal:

European Journal of Immunology

Year:

1997

Language:

english

File:

PDF, 1.05 MB

english, 1997

6

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

Johnston, James A., Kawamura, Masaru, Kirken, Robert A., Chen, Yi-Qing, Blake, Trevor B., Shibuya, Kyoichi, Ortaldo, John R., McVicar, Daniel W., O'Shea, John J.

Journal:

Year:

1994

File:

PDF, 370 KB

1994

7

Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways

Zsuzsanna S. Nagy, Jeremy A. Ross, Georgialina Rodriguez, Julia Bader, Jonathan Dimmock, Robert A. Kirken

Journal:

Year:

2010

Language:

english

File:

PDF, 634 KB

english, 2010

8

Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor β-chain

Robert A. Kirken, Hallgeir Rui, Grazia M. Malabarba, Zack O.M. Howard, Masura Kawamura, John J. O 'Shea, William L. Farrar

Journal:

Year:

1995

Language:

english

File:

PDF, 235 KB

english, 1995

9

High Yield Purification of a Four Subunit caa3-Type Cytochrome Oxidase from the Thermophilic Bacterium Bacillus PS3 Using Fast Protein Liquid Chromatography

R.A. Kirken, A.J. Lincoln, P.S. Fink, L.J. Prochaska

Journal:

Protein Expression and Purification

Year:

1995

File:

PDF, 875 KB

1995

10

Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580

Luis DaSilva, Hallgeir Rui, Rebecca A. Erwin, O.M. Zack Howard, Robert A. Kirken, Maria G. Malabarba, Rebecca H. Hackett, Andrew C. Larner, William L. Farrar

Journal:

Molecular and Cellular Endocrinology

Year:

1996

Language:

english

File:

PDF, 1.25 MB

english, 1996

11

184 The NFκB regulator Bcl10 is a novel Stat5 target gene

Zsuzsanna S. Nagy, Matthew J. LeBaron, Hallgeir Rui, Robert A. Kirken

Journal:

Year:

2008

Language:

english

File:

PDF, 46 KB

english, 2008

12

Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection

M.-E Wang, R Kirken, F Behbod, R Erwin-Cohen, S.M Stepkowski, B.D Kahan

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 60 KB

english, 2001

13

Tolerance induction by alteration of T cell receptor (TCR) signaling using an allochimeric donor/recipient class I MHC protein

S.M Stepkowski, R.A Kirken, M Wang, J Yu, K Akioka, B.D Kahan

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 59 KB

english, 2001

14

Selective inhibition of IL-2 mRNA blocks allograft rejection by limiting T cell clonal expansion

L Tian, X Qu, M.E Wang, R.A Kirken, F.C Bennett, S.M Stepkowski

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 60 KB

english, 2001

15

Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts

R.A Kirken, R Erwin-Cohen, F Behbod, M.-E Wang, S.M Stepkowski, B.D Kahan

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 58 KB

english, 2001

16

Targeting Jak3 for immune suppression and allograft acceptance

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 119 KB

english, 2001

17

PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection

S.M. Stepkowski, Z.S. Nagy, M.-E. Wang, F. Behbod, R. Erwin-Cohen, B.D. Kahan, R.A. Kirken

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 44 KB

english, 2001

18

The role of Stat5 in the induction of regulatory t cells in transplantation tolerance

S.M. Stepkowski, R.A. Kirken, Z.S. Nagy, B.W. Trawick, M. Wang, N. Tejpal, M.-E. Wang, L. Tian, J. Clark, B.D. Kahan

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 48 KB

english, 2001

19

The role of signals 1, 2, and 3 in induction of transplantation tolerance

S.M. Stepkowski, Z.S. Nagy, B.D. Kahan, R.A. Kirken

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 49 KB

english, 2001

20

Molecular actions of sirolimus: sirolimus and mTor

R.A Kirken, Y.L Wang

Journal:

Transplantation Proceedings

Year:

2003

Language:

english

File:

PDF, 98 KB

english, 2003

21

New approaches to transplant immunosuppression

B.D. Kahan, R.A. Kirken, S.M. Stepkowski

Journal:

Transplantation Proceedings

Year:

2003

Language:

english

File:

PDF, 59 KB

english, 2003

22

Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models

Robert A Kirken, Gerald A Evans, Roy J Duhé, Luis DaSilva, M.Grazia Malabarba, Rebecca A Erwin, William L Farrar

Journal:

Veterinary Immunology and Immunopathology

Year:

1998

Language:

english

File:

PDF, 183 KB

english, 1998

23

Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression

Hiroko Yamashita, Marja T Nevalainen, Jun Xu, Matthew J LeBaron, Kay-Uwe Wagner, Rebecca A Erwin, Jeffrey M Harmon, Lothar Hennighausen, Robert A Kirken, Hallgeir Rui

Journal:

Molecular and Cellular Endocrinology

Year:

2001

Language:

english

File:

PDF, 529 KB

english, 2001

24

Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family

Luis DaSilva, Robert A. Kirken, Dennis D. Taub, Gerald A. Evans, Roy J. Duhé, Melissa A. Bailey, William L. Farrar

Journal:

Year:

1998

Language:

english

File:

PDF, 442 KB

english, 1998

25

STAT5 regulation of BCL10 parallels constitutive NFκB activation in lymphoid tumor cells

Zsuzsanna S Nagy, Matthew J LeBaron, Jeremy A Ross, Abhisek Mitra, Hallgeir Rui, Robert A Kirken

Journal:

Molecular Cancer

Year:

2009

Language:

english

File:

PDF, 2.09 MB

english, 2009

26

Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies

Ross, J A, Spadaro, M, Rosado, D C, Cavallo, F, Kirken, R A, Pericle, F

Journal:

Year:

2014

Language:

english

File:

PDF, 1.30 MB

english, 2014

27

TRANSCRIPTION FACTOR STAT5 SYNERGIZES WITH ANDROGEN RECEPTOR IN PROSTATE CANCER CELLS

Liao, Zhiyong, Tan, Shyh-Han, Dagvadorj, Ayush, Shen, Feng, Gu, Lei, Abdulghani, Junaid, Zhang, Ying, Gelmann, Edward P, Zellweger, Tobias, Culig, Zoran, Visakorpi, Tapio, Bubendorf, Lukas, Kirken, Ro

Journal:

The Journal of Urology

Year:

2008

Language:

english

File:

PDF, 125 KB

english, 2008

28

TRANSCRIPTION FACTOR STAT5 PROMOTES GROWTH OF HUMAN PROSTATE CANCER CELLS IN VIVO

Dagvadorj, Ayush, Kirken, Robert A, Karras, James, Nevalainen, Marja T

Journal:

The Journal of Urology

Year:

2008

Language:

english

File:

PDF, 155 KB

english, 2008

29

Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction

Kirken, Robert A., Rui, Hallgeir, Howard, O.M.Zack, Farrar, William L.

Journal:

Progress in Growth Factor Research

Year:

1994

Language:

english

File:

PDF, 2.41 MB

english, 1994

30

Nitric Oxide and Thiol Redox Regulation of Janus Kinase Activity

Roy J. Duhe, Gerald A. Evans, Rebecca A. Erwin, Robert A. Kirken, George W. Cox and William L. Farrar

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.61 MB

english, 1998

31

Unique advantage of Janus kinase 3 as a target for selective and nontoxic immunosupression

Stepkowski, Stanislaw M, Kirken, Robert A

Journal:

Expert Review of Clinical Immunology

Year:

2005

Language:

english

File:

PDF, 71 KB

english, 2005

32

The PHB1/2 Phosphocomplex Is Required for Mitochondrial Homeostasis and Survival of Human T Cells

Ross, J. A., Nagy, Z. S., Kirken, R. A.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.39 MB

english, 2008

33

A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor

Nagy, Z. S., Rui, H., Stepkowski, S. M., Karras, J., Kirken, R. A.

Journal:

The Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 553 KB

english, 2006

34

Involvement of the Ubiquitin-Proteasome Pathway in the Degradation of Nontyrosine Kinase-Type Cytokine Receptors of IL-9, IL-2, and Erythropoietin

Yen, C.-H., Yang, Y.-C., Ruscetti, S. K., Kirken, R. A., Dai, R. M., Li, C.-C. H.

Journal:

The Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 3.28 MB

english, 2000

35

Signal Transducer and Activator of Transcription 5b (Stat5b) Serine 193 Is a Novel Cytokine-induced Phospho-regulatory Site That Is Constitutively Activated in Primary Hematopoietic Malignancies

Mitra, A., Ross, J. A., Rodriguez, G., Nagy, Z. S., Wilson, H. L., Kirken, R. A.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 4.33 MB

english, 2012

36

Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts

Behbod, F., Erwin-Cohen, R. A., Wang, M.-E., Trawick, B. W., Qu, X., Verani, R., Kahan, B. D., Stepkowski, S. M., Kirken, R. A.

Journal:

The Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 3.05 MB

english, 2001

37

Protein Phosphatase 2A Regulates Interleukin-2 Receptor Complex Formation and JAK3/STAT5 Activation

Ross, J. A., Cheng, H., Nagy, Z. S., Frost, J. A., Kirken, R. A.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 1.70 MB

english, 2010

38

The Mannich Base NC1153 Promotes Long-Term Allograft Survival and Spares the Recipient from Multiple Toxicities

Stepkowski, S. M., Kao, J., Wang, M.-E., Tejpal, N., Podder, H., Furian, L., Dimmock, J., Jha, A., Das, U., Kahan, B. D., Kirken, R. A.

Journal:

The Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 1.25 MB

english, 2005

39

Prolactin Stimulates Serine/Tyrosine Phosphorylation and Formation of Heterocomplexes of Multiple Stat5 Isoforms in Nb2 Lymphocytes

Kirken, R. A., Malabarba, M. G., Xu, J., Liu, X., Farrar, W. L., Hennighausen, L., Larner, A. C., Grimley, P. M., Rui, H.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 871 KB

english, 1997

40

Activation of JAK3, but Not JAK1, Is Critical to Interleukin-4 (IL4) Stimulated Proliferation and Requires a Membrane-proximal Region of IL4 Receptor [IMAGE]

Journal:

Journal of Biological Chemistry

Year:

1995

File:

PDF, 13.12 MB

1995

41

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6: ROLES FOR MULTIPLE PHOSPHORYLATION SITES AND Stat6 FUNCTION

Wang, Y., Malabarba, M. G., Nagy, Z. S., Kirken, R. A.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 841 KB

english, 2004

42

Allograft Rejection Requires STAT5a/b-Regulated Antiapoptotic Activity in T Cells but Not B Cells

Zhang, Y., Kirken, R. A., Furian, L., Janczewska, S., Qu, X., Hancock, W. W., Wang, M., Tejpal, N., Kerman, R., Kahan, B. D., Stepkowski, S. M.

Journal:

The Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 1.16 MB

english, 2006

43

Forskolin-inducible cAMP Pathway Negatively Regulates T-cell Proliferation by Uncoupling the Interleukin-2 Receptor Complex

Rodriguez, G., Ross, J. A., Nagy, Z. S., Kirken, R. A.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 3.45 MB

english, 2013

44

Functional Uncoupling of the Janus Kinase 3-Stat5 Pathway in Malignant Growth of Human T Cell Leukemia Virus Type 1-Transformed Human T Cells

Kirken, R. A., Erwin, R. A., Wang, L., Wang, Y., Rui, H., Farrar, W. L.

Journal:

The Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 1.33 MB

english, 2000

45

Specific Inhibition of Stat5a/b Promotes Apoptosis of IL-2-Responsive Primary and Tumor-Derived Lymphoid Cells

Behbod, F., Nagy, Z. S., Stepkowski, S. M., Karras, J., Johnson, C. R., Jarvis, W. D., Kirken, R. A.

Journal:

The Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 789 KB

english, 2003

46

Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells

Yamashita, H., Xu, J., Erwin, R. A., Farrar, W. L., Kirken, R. A., Rui, H.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 828 KB

english, 1998

47

Transcription Factor Signal Transducer and Activator of Transcription 5 Promotes Growth of Human Prostate Cancer Cells In vivo

Dagvadorj, A., Kirken, R. A., Leiby, B., Karras, J., Nevalainen, M. T.

Journal:

Clinical Cancer Research

Year:

2008

Language:

english

File:

PDF, 690 KB

english, 2008

48

Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells

Tan, S.-H., Dagvadorj, A., Shen, F., Gu, L., Liao, Z., Abdulghani, J., Zhang, Y., Gelmann, E. P., Zellweger, T., Culig, Z., Visakorpi, T., Bubendorf, L., Kirken, R. A., Karras, J., Nevalainen, M. T.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 1024 KB

english, 2008

49

Two Discrete Regions of Interleukin-2 (IL2) Receptor Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase

Kirken, R. A., Malabarba, M. G., Xu, J., DaSilva, L., Erwin, R. A., Liu, X., Hennighausen, L., Rui, H., Farrar, W. L.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 869 KB

english, 1997

50

Phosphorylation of Human Jak3 at Tyrosines 904 and 939 Positively Regulates Its Activity

Cheng, H., Ross, J. A., Frost, J. A., Kirken, R. A.

Journal:

Molecular and Cellular Biology

Year:

2008

Language:

english

File:

PDF, 967 KB

english, 2008

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